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T K Hart Selected Research

keliximab

9/2002Practical aspects of including functional endpoints in developmental toxicity studies. Case study: immune function in HuCD4 transgenic mice exposed to anti-CD4 MAb in utero.
2/2001Immunomodulatory effects of anti-CD4 antibody in host resistance against infections and tumors in human CD4 transgenic mice.
4/2000Preclinical development of keliximab, a Primatized anti-CD4 monoclonal antibody, in human CD4 transgenic mice: characterization of the model and safety studies.

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T K Hart Research Topics

Disease

3Infections
09/2002 - 04/2000
2Asthma (Bronchial Asthma)
10/2002 - 08/2001
2Experimental Melanoma
02/2001 - 04/2000
2Neoplasms (Cancer)
02/2001 - 04/2000
1Ischemia
11/2001
1Myocardial Infarction
11/2001
1Reperfusion Injury
11/2001
1Respiratory Tract Diseases (Respiratory Tract Disease)
08/2001
1Eosinophilia
08/2001
1Autoimmune Diseases (Autoimmune Disease)
02/2001
1Neoplasm Metastasis (Metastasis)
02/2001

Drug/Important Bio-Agent (IBA)

3keliximabIBA
09/2002 - 04/2000
2Monoclonal AntibodiesIBA
10/2002 - 08/2001
1Interleukin-4 (Interleukin 4)IBA
10/2002
1InterleukinsIBA
10/2002
1CytokinesIBA
10/2002
1Immunoglobulin E (IgE)IBA
10/2002
1L-SelectinIBA
11/2001
1Rosiglitazone (Avandia)FDA Link
11/2001
1PPAR-gamma AgonistsIBA
11/2001
1Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
11/2001
1Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
11/2001
1Interleukin-5 (Interleukin 5)IBA
08/2001
1Interleukin-6 (Interleukin 6)IBA
08/2001
1mepolizumabIBA
08/2001
1Chemokine CCL5IBA
08/2001
1AntibodiesIBA
02/2001
1Thomsen-Friedenreich antibodiesIBA
02/2001
1Adrenal Cortex Hormones (Corticosteroids)IBA
02/2001

Therapy/Procedure

2Therapeutics
08/2001 - 02/2001